21-year-old Jobe will remain with the Us for the next three years.
The defender was signed to the League One club following an impressive spell at Royston Town in 2020.
He excelled whilst at Gateshead in the National League last season on loan, before rejoining the First Team in April this year.
Manadou said:
"I am really happy to be signing a new contract with the Club.
The Manager has shown a lot of faith in me since he came into the Club and he has given me a lot of confidence that I am ready to be playing League One football.
I can’t wait to get started again for the new season, to have a full pre-season with the boys under my belt and kick on again".
Cambridge United Head Coach Garry Monk added:
"We are all delighted that Mamadou has chosen to continue his journey with Cambridge United.
Mamadou showed at the end of last season he is ready to impact his potential on the team.
As a Club It is really important that we retain our talented young players and continue to develop them both on and off the pitch".
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